An ideal tool forcontinuous solvent drying

CMS’ membrane pervaporation system is an ideal tool for the dehydration of solvents in flow and batch chemistry applications, allowing in-line purification of solvents.

Solvents represent an important component for API production, particularly in the growth area of continuous processing systems.

  • Dry, high purity solvents increase reaction yield and production
  • Reusing solvents is beneficial both economically and environmentally
  • CMS creates custom solutions tailored to your needs
Drying Solvent

Drying solvent enhances API production:

  • Deliver superior process performance

    Drier solvent improves yield and purity
  • Enable new synthetic pathways

    Membrane systems deliver on-demand dry solvent that may not be available commercially in an anhydrous state
  • Support flow chemistry

    Continuously drying process solvents at any scale from mL/min to gal/min

Strength of CMS technology

Product Performance

  • Water goes through the membrane, making the system ideal for removing water from solvent
  • Azeotropes are not an issue for CMS pervaporation technology
  • System flexibility to meet specific goals– ability to trade off purity and recovery

Customer Value

  • Many chemistries are water sensitive, so excess water impacts scalability, yield, performance, and presence of side reactions
  • Distillation or evaporation cannot always attain the desired purity and does not scale down well for flow processes
  • Membrane systems can be optimized for individual chemistries and processes with unique compatibility and design needs

Compatible with a variety of solvents

  • Ethanol
  • Xylene
  • Butanol
  • Acetone
  • Ethylbenzene
  • Benzene
  • Chlorobenzene
  • Tetrahydrofuran (THF)
  • Methyl isobutyl ketone (MIBK)
  • Methyl tert-butyl ether (MTBE)
  • Isopropanol (IPA)
  • Hexane
  • Cyclohexane
  • Ethyl acetate

How we work with you forcustom solutions

Separation Needs

1. Understanding customer's separation need

Target separation
Target solvent dryness and recovery
Drawbacks/limitations of alternative drying methods
Desired flow rate
Batch or continuous process
Ideal and acceptable drying temperature range
Safety considerations

Design considerations


2. Quick feasibility assessment based on similar solvents

CMS uses extensive solvent drying data set to find separation with similar chemistry and composition.

CMS data is coupled with customer separation details to provide an estimate estimate of the number required membranes to meet the drying specification.

Feasibility Test

3. Feasibility test

Customer Provides

  • 1-3 gallon sample material
  • Sample material(s) SDS
  • Sample water concentration
  • Target solvent dryness/purity
  • Maximum allowable solvent loss
  • Sample material limitations
    • liquid-side pressure drop
    • maximum temperature
    • inventory/hold-up volume
CMS conducts lab test

Customer Receives

  • Drying feasibility (yes/no)
  • Membrane count for full system
  • Practically achievable drying level
  • Solvent loss to permeate
  • Dried sample material along with permeate

4. Agree on important design parameters with customer

Flow rates
Ideal temperature range
Safety rating (explosion proof)
Holdup volumes
Integration points
Vacuum source
Available utilities

5. Example membrane bank for continuous solvent drying application

6. System build

Upon agreement on the system design CMS will build a custom dehydration system. If necessary CMS will bring in an outside fabrication team to facilitate the system build.

System Build
System installation

7. Membrane system installation

The system pictured to the left was operational and producing on-spec, dry solvent within 3 days of arrival.

Case Study

Objective – Safely use anhydrous TBHP for scaleup of a molecule

Li, B., et al, Continuous Production of Anhydrous tert-Butyl Hydroperoxide in Nonane Using Membrane Pervaporation and its Application in Flow Oxidation of a γ-Butyrolactam, Submitted to OPRD, 2018.


Need a method to continuously and safely dehydrate TBHP to 1000 ppm water.


CMS tested TBHP process material in-house and generated system design for continuous drying.

Solution designed to work at near-ambient temperature to ensure safe operation.

Drying system operational with minimal operator intervention
TBHP inventory kept low by designing system for continuous,
in-line production of dry process material for downstream use
Operating conditions tied to automated data acquisition to automated data acquisition to give customer ample diagnostics.